Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis.

ABSTRACT:

Importance

Aortic stenosis (AS) has no approved medical treatment. Identifying etiological pathways for AS could identify pharmacological targets.

Objective

To identify novel genetic loci and pathways associated with AS.

Design, setting, and participants

This genome-wide association study used a case-control design to evaluate 44 703 participants (3469 cases of AS) of self-reported European ancestry from the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort (from January 1, 1996, to December 31, 2015). Replication was performed in 7 other cohorts totaling 256 926 participants (5926 cases of AS), with additional analyses performed in 6942 participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Follow-u

SUBMITTER: Chen HY 

PROVIDER: S-EPMC7081150 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature