High expression of COPB2 predicts adverse outcomes: A potential therapeutic target for glioma.

ABSTRACT:

Aims

To evaluate the clinical significance of coatomer protein complex subunit beta 2 (COPB2) in patients with glioma using a bioinformatics analysis.

Methods

Oncomine, GEO, and The Cancer Genome Atlas databases were used to examine the COPB2 transcript levels in glioma tissues. Gene expression profiles with clinical information from low-grade glioma and glioblastoma (GBM) projects were analyzed for associations between COPB2 expression and clinicopathologic characteristics. Kaplan-Meier survival and Cox regression analyses were used for survival analysis. Gene set enrichment analysis (GSEA) was conducted to screen the pathways involved in COPB2 expression. Gene set variation analysis (GSVA) and correlograms were performed to verify the correlations between COPB2 and inflamm

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC7081167 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature