Association of dopamine D2 receptor and leptin receptor genes with clinically severe obesity.

ABSTRACT:

Objective

The brain reward circuits that promote drug abuse may also be involved in pleasure seeking behavior and food cravings observed in severely obese subjects. Drug addiction polymorphisms such as the TaqI A1 allele of the dopamine D2 receptor (DRD2) are associated with cocaine, alcohol, and opioid use, but few studies have linked DRD2 to food craving. Other genes such as the leptin receptor gene (LEPR) and mu-opioid receptor gene (OPRM1) that affect appetite and pleasure centers in the brain may also influence food addiction and obesity. The three genes together may function synergistically.

Design and methods

To evaluate associations between candidate genes, food craving, overeating, and BMI, we administered questionnaires including Power of Food Scale and Food Cravin

SUBMITTER: Carpenter CL 

PROVIDER: S-EPMC7081169 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature