A metabolic switch regulates the transition between growth and diapause in C. elegans.

ABSTRACT: BACKGROUND:Metabolic activity alternates between high and low states during different stages of an organism's life cycle. During the transition from growth to quiescence, a major metabolic shift often occurs from oxidative phosphorylation to glycolysis and gluconeogenesis. We use the entry of Caenorhabditis elegans into the dauer larval stage, a developmentally arrested stage formed in response to harsh environmental conditions, as a model to study the global metabolic changes and underlying molecular mechanisms associated with growth to quiescence transition. RESULTS:Here, we show that the metabolic switch involves the concerted activity of several regulatory pathways. Whereas the steroid hormone receptor DAF-12 controls dauer morphogenesis, the insulin pathway maintains low energy expend

SUBMITTER: Penkov S 

PROVIDER: S-EPMC7081555 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature