Tubular bile duct structure mimicking bile duct morphogenesis for prospective in vitro liver metabolite recovery.

ABSTRACT:

Background

Liver metabolites are used to diagnose disease and examine drugs in clinical pharmacokinetics. Therefore, development of an in vitro assay system that reproduces liver metabolite recovery would provide important benefits to pharmaceutical research. However, liver models have proven challenging to develop because of the lack of an appropriate bile duct structure for the accumulation and transport of metabolites from the liver parenchyma. Currently available bile duct models, such as the bile duct cyst-embedded extracellular matrix (ECM), lack any morphological resemblance to the tubular morphology of the living bile duct. Moreover, these systems cannot overcome metabolite recovery issues because they are established in isolated culture systems. Here, we successfully estab

SUBMITTER: Rizki-Safitri A 

PROVIDER: S-EPMC7081557 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature