Dynamic LTR retrotransposon transcriptome landscape in septic shock patients.

ABSTRACT:

Background

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Numerous studies have explored the complex and dynamic transcriptome modulations observed in sepsis patients, but a large fraction of the transcriptome remains unexplored. This fraction could provide information to better understand sepsis pathophysiology. Multiple levels of interaction between human endogenous retroviruses (HERV) and the immune response have led us to hypothesize that sepsis is associated with HERV transcription and that HERVs may contribute to a signature among septic patients allowing stratification and personalized management.

Methods

We used a high-density microarray and RT-qPCR to evaluate the HERV and Mammalian Apparent Long Termin

SUBMITTER: Mommert M 

PROVIDER: S-EPMC7081582 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature