Characterization and applications of chimeric mice with humanized livers for preclinical drug development.

ABSTRACT: We have succeeded in stable mass production of chimeric PXB-mice, whose liver is repopulated by human hepatocytes at a ratio of more than 70%, and we are providing these mice to academia and pharmaceutical companies to support the development of new drugs or studies of liver function. Furthermore, we isolated human hepatocytes, called PXB-cells, from the chimeric mice, and provide them for clients weekly for in vitro studies. In this review, we summarize the existing characterizations of PXB-mice and PXB-cells and their present and future applications.

SUBMITTER: Tateno C 

PROVIDER: S-EPMC7081693 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature