Metastatic breast cancer cells induce altered microglial morphology and electrical excitability in vivo.

ABSTRACT:

Background

An emerging problem in the treatment of breast cancer is the increasing incidence of metastases to the brain. Metastatic brain tumours are incurable and can cause epileptic seizures and cognitive impairment, so better understanding of this niche, and the cellular mechanisms, is urgently required. Microglia are the resident brain macrophage population, becoming "activated" by neuronal injury, eliciting an inflammatory response. Microglia promote proliferation, angiogenesis and invasion in brain tumours and metastases. However, the mechanisms underlying microglial involvement appear complex and better models are required to improve understanding of function.

Methods

Here, we sought to address this need by developing a model to study metastatic breast cancer cell-mic

SUBMITTER: Simon A 

PROVIDER: S-EPMC7081703 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature