Prospective study on the effect of short-term androgen deprivation therapy on PSMA uptake evaluated with ⁶⁸Ga-PSMA-11 PET/MRI in men with treatment-naive prostate cancer.

ABSTRACT:

Purpose

Based on in vitro studies, it is known that androgen deprivation therapy (ADT) increases prostate-specific membrane antigen (PSMA) expression. Therefore, we hypothesised that ADT improves the performance of PSMA-PET imaging in primary staging of prostate cancer. The purpose of the study was to demonstrate the time course effect of ADT on PSMA uptake in different types of metastatic lesions evaluated with ⁶⁸Ga-PSMA-11 PET/MRI.

Methods

Nine men with treatment-naïve prostate cancer were enrolled to a prospective, registered (NCT03313726) clinical trial. A ⁶⁸Ga-PSMA-11 PET/MRI was performed once before and 3 times post-ADT (degarelix, Firmagon). Change of maximum standardised uptake values (SUVmax) in prostate, lymph nodes, bone metastases, and phys

SUBMITTER: Ettala O 

PROVIDER: S-EPMC7081750 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature