CircParser: a novel streamlined pipeline for circular RNA structure and host gene prediction in non-model organisms.

ABSTRACT: Circular RNAs (circRNAs) are long noncoding RNAs that play a significant role in various biological processes, including embryonic development and stress responses. These regulatory molecules can modulate microRNA activity and are involved in different molecular pathways as indirect regulators of gene expression. Thousands of circRNAs have been described in diverse taxa due to the recent advances in high throughput sequencing technologies, which led to a huge variety of total RNA sequencing being publicly available. A number of circRNA de novo and host gene prediction tools are available to date, but their ability to accurately predict circRNA host genes is limited in the case of low-quality genome assemblies or annotations. Here, we present CircParser, a simple and fast Unix/Linux pipelin

SUBMITTER: Nedoluzhko A 

PROVIDER: S-EPMC7081776 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature