An African origin for Mycobacterium bovis.

ABSTRACT:

Background and objectives

Mycobacterium bovis and Mycobacterium caprae are two of the most important agents of tuberculosis in livestock and the most important causes of zoonotic tuberculosis in humans. However, little is known about the global population structure, phylogeography and evolutionary history of these pathogens.

Methodology

We compiled a global collection of 3364 whole-genome sequences from M.bovis and M.caprae originating from 35 countries and inferred their phylogenetic relationships, geographic origins and age.

Results

Our results resolved the phylogenetic relationship among the four previously defined clonal complexes of M.bovis, and another eight newly described here. Our phylogeographic analysis showed that M.bo

SUBMITTER: Loiseau C 

PROVIDER: S-EPMC7081938 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature