Early KLRG1⁺ but Not CD57⁺CD8⁺ T Cells in Primary Cytomegalovirus Infection Predict Effector Function and Viral Control.

ABSTRACT: CMV remains an important opportunistic pathogen in high-risk lung transplant recipients. We characterized the phenotype and function of CD8⁺ T cells from acute/primary into chronic CMV infection in 23 (donor+/recipient-; D+R-) lung transplant recipients and found rapid induction of both KLRG1⁺ and/or CD57⁺ CMV-specific CD8⁺ T cells with unexpected coexpression of CD27. These cells demonstrated maturation from an acute effector T cell (T_AEFF) to an effector memory T cell (T_EM) phenotype with progressive enrichment of KLRG1⁺CD57⁺CD27^- cells into memory. CMV-specific KLRG1⁺ T_AEFF were capable of in vitro proliferation that diminished upon acquisition of CD57, whereas only K

SUBMITTER: Hoji A 

PROVIDER: S-EPMC7081945 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature