Plasma Glycated CD59 Predicts Early Gestational Diabetes and Large for Gestational Age Newborns.

ABSTRACT:

Context

Gestational diabetes mellitus (GDM) diagnosed in early pregnancy is a health care challenge because it increases the risk of adverse outcomes. Plasma-glycated CD59 (pGCD59) is an emerging biomarker for diabetes and GDM. The aim of this study was to assess the performance of pGCD59 as a biomarker of early GDM and its association with delivering a large for gestational age (LGA) infant.

Objectives

To assess the performance of pGCD59 to identify women with GDM in early pregnancy (GDM < 20) and assess the association of pGCD59 with LGA and potentially others adverse neonatal outcomes linked to GDM.

Methods

Blood levels of pGCD59 were measured in samples from 693 obese women (body mass index > 29) undergoing a 75-g, 2-hour oral glucose tolerance test (OGTT) at <20

SUBMITTER: Ma D 

PROVIDER: S-EPMC7082084 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature