Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars.

ABSTRACT:

Objective

Nonalcoholic fatty liver disease (i.e., increased intrahepatic triglyceride [IHTG] content), predisposes to type 2 diabetes and cardiovascular disease. Adipose tissue lipolysis and hepatic de novo lipogenesis (DNL) are the main pathways contributing to IHTG. We hypothesized that dietary macronutrient composition influences the pathways, mediators, and magnitude of weight gain-induced changes in IHTG.

Research design and methods

We overfed 38 overweight subjects (age 48 ± 2 years, BMI 31 ± 1 kg/m², liver fat 4.7 ± 0.9%) 1,000 extra kcal/day of saturated (SAT) or unsaturated (UNSAT) fat or simple sugars (CARB) for 3 weeks. We measured IHTG (¹H-MRS), pathways contributing to IHTG (lipolysis ([²H₅]glycerol) and DNL (²

SUBMITTER: Luukkonen PK 

PROVIDER: S-EPMC7082640 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature