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Nanoparticles based on the zwitterionic pillar[5]arene and Ag⁺: synthesis, self-assembly and cytotoxicity in the human lung cancer cell line A549.

ABSTRACT: For the first time, stable pillar[5]arene/Ag⁺ nanoparticles, consisting of water-soluble pillar[5]arene containing γ-sulfobetaine fragments and Ag⁺ ions without Ag-Ag bonds, were synthesized and characterized. The pillar[5]arene/Ag⁺ (ratio 1:10) nanoparticles obtained were cubic with a rib length of 100 nm and are less cytotoxic than Ag⁺ ions. The survival of the A549 model cells in the presence of pillar[5]arene/Ag⁺ (1:10) nanoparticles at a concentration of 30 and 40 μM was 76% and 55%, while in the absence of pillar[5]arene, the cell survival for free Ag⁺ ions at the same concentration was 30% and 10%, respectively. The results can be used to create new antibacterial materials and 2D biomedical coatings.

SUBMITTER: Shurpik DN

PROVIDER: S-EPMC7082700 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Nanoparticles based on the zwitterionic pillar[5]arene and Ag+: synthesis, self-assembly and cytotoxicity in the human lung cancer cell line A549.

Shurpik Dmitriy N DN Sevastyanov Denis A DA Zelenikhin Pavel V PV Padnya Pavel L PL Evtugyn Vladimir G VG Osin Yuriy N YN Stoikov Ivan I II

Beilstein journal of nanotechnology 20200305

For the first time, stable pillar[5]arene/Ag+ nanoparticles, consisting of water-soluble pillar[5]arene containing γ-sulfobetaine fragments and Ag+ ions without Ag-Ag bonds, were synthesized and characterized. The pillar[5]arene/Ag+ (ratio 1:10) nanoparticles obtained were cubic with a rib length of 100 nm and are less cytotoxic than Ag+ ions. The survival of the A549 model cells in the presence of pillar[5]arene/Ag+ (1:10) nanoparticles at ...[more]

PMID: 32215229

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