Cis-regulatory analysis of Onecut1 expression in fate-restricted retinal progenitor cells.

ABSTRACT:

Background

The vertebrate retina consists of six major classes of neuronal cells. During development, these cells are generated from a pool of multipotent retinal progenitor cells (RPCs) that express the gene Vsx2. Fate-restricted RPCs have recently been identified, with limited mitotic potential and cell fate possibilities compared to multipotent RPCs. One population of fate-restricted RPCs, marked by activity of the regulatory element ThrbCRM1, gives rise to both cone photoreceptors and horizontal cells. These cells do not express Vsx2, but co-express the transcription factors (TFs) Onecut1 and Otx2, which bind to ThrbCRM1. The components of the gene regulatory networks that control the transition from multipotent to fate-restricted gene expression are not known. This work aims t

SUBMITTER: Patoori S 

PROVIDER: S-EPMC7082998 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature