Genomic and Transcriptomic Landscape of Tumor Clonal Evolution in Cholangiocarcinoma.

ABSTRACT: Cholangiocarcinoma remained a severe threat to human health. Deciphering the genomic and/or transcriptomic profiles of tumor has been proved to be a promising strategy for exploring the mechanism of tumorigenesis and development, which could also provide valuable insights into Cholangiocarcinoma. However, little knowledge has been obtained regarding to how the alteration among different omics levels is connected. Here, using whole exome sequencing and transcriptome sequencing, we performed a thorough evaluation for the landscape of genome and transcriptome in cholangiocarcinoma and illustrate the alteration of tumor on different biological levels. Meanwhile, we also identified the clonal structure of each included tumor sample and discovered different clonal evolution patterns related to p

SUBMITTER: Chen G 

PROVIDER: S-EPMC7083074 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature