Longitudinal Changes of Fixation Location and Stability Within 12 Months in Stargardt Disease: ProgStar Report No. 12.

ABSTRACT:

Purpose

To investigate the natural history of Stargardt disease (STGD1) using fixation location and fixation stability.

Design

Multicenter, international, prospective cohort study.

Methods

Fixation testing was performed using the Nidek MP-1 microperimeter as part of the prospective, multicenter, natural history study on the Progression of Stargardt disease (ProgStar). A total of 238 patients with ABCA4-related STGD1 were enrolled at baseline (bilateral enrollment in 86.6%) and underwent repeat testing at months 6 and 12.

Results

Outcome measures included the distance of the preferred retinal locus from the fovea (PRL) and the bivariate contour ellipse area (BCEA). After 12 months of follow-up, the change in the eccentricity of the PRL from the anatomic fovea wa

SUBMITTER: Schonbach EM 

PROVIDER: S-EPMC7083180 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature