Striatal Dopamine D₂-Muscarinic Acetylcholine M₁ Receptor-Receptor Interaction in a Model of Movement Disorders.

ABSTRACT: Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor control deficits, which is associated with the loss of striatal dopaminergic neurons from the substantia nigra. In parallel to dopaminergic denervation, there is an increase of acetylcholine within the striatum, resulting in a striatal dopaminergic-cholinergic neurotransmission imbalance. Currently, available PD pharmacotherapy (e.g., prodopaminergic drugs) does not reinstate the altered dopaminergic-cholinergic balance. In addition, it can eventually elicit cholinergic-related adverse effects. Here, we investigated the interplay between dopaminergic and cholinergic systems by assessing the physical and functional interaction of dopamine D₂ and muscarinic acetylcholine M₁ receptors (D

SUBMITTER: Crans RAJ 

PROVIDER: S-EPMC7083216 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature