Abnormal patterns of corticomuscular and intermuscular coherence in childhood dystonia.

ABSTRACT:

Objective

Sensorimotor processing is abnormal in Idiopathic/Genetic dystonias, but poorly studied in Acquired dystonias. Beta-Corticomuscular coherence (CMC) quantifies coupling between oscillatory electroencephalogram (EEG) and electromyogram (EMG) activity and is modulated by sensory stimuli. We test the hypothesis that sensory modulation of CMC and intermuscular coherence (IMC) is abnormal in Idiopathic/Genetic and Acquired dystonias.

Methods

Participants: 11 children with Acquired dystonia, 5 with Idiopathic/Genetic dystonia, 13 controls (12-18 years). CMC and IMC were recorded during a grasp task, with mechanical perturbations provided by an electromechanical tapper. Coherence patterns pre- and post-stimulus were compared across groups.

Results

Beta-CMC increased

SUBMITTER: McClelland VM 

PROVIDER: S-EPMC7083222 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature