White Blood Cell Count and Risk of Incident Lung Cancer in the UK Biobank.

ABSTRACT:

Background

The contribution of measurable immunological and inflammatory parameters to lung cancer development remains unclear, particularly among never smokers. We investigated the relationship between total and differential white blood cell (WBC) counts and incident lung cancer risk overall and among subgroups defined by smoking status and sex in the United Kingdom (UK).

Methods

We evaluated 424 407 adults aged 37-73 years from the UK Biobank. Questionnaires, physical measurements, and blood were administered and collected at baseline in 2006-2010. Complete blood cell counts were measured using standard methods. Lung cancer diagnoses and histological classifications were obtained from cancer registries. Multivariable Cox regression models were used to estimate the hazard r

SUBMITTER: Wong JYY 

PROVIDER: S-EPMC7083262 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature