Exploring the overlap between rheumatoid arthritis susceptibility loci and long non-coding RNA annotations.

ABSTRACT: Whilst susceptibility variants for many complex diseases, such as rheumatoid arthritis (RA), have been well characterised, the mechanism by which risk is mediated is still unclear for many loci. This is especially true for the majority of variants that do not affect protein-coding regions. lncRNA represent a group of molecules that have been shown to be enriched amongst variants associated with RA and other complex diseases, compared to random variants. In order to establish to what degree direct disruption of lncRNA may represent a potential mechanism for mediating RA susceptibility, we chose to further explore this overlap. By testing the ability of annotated features to improve a model of disease susceptibility, we were able to demonstrate a local enrichment of enhancers from immune-rel

SUBMITTER: Ding J 

PROVIDER: S-EPMC7083320 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature