Association of leptin and leptin receptor polymorphisms with coronary artery disease in a North Chinese Han population.

ABSTRACT:

Introduction

Leptin (LEP) is a peptide hormone that acts via leptin receptor (LEPR) binding. Genetic evidence from different human populations has implicated LEP/LEPR in the pathogenesis of coronary artery disease (CAD), and suggests that certain LEP/LEPR gene polymorphisms may increase the risk of CAD. The aim of this study was to assess two single nucleotide polymorphisms (SNPs) in LEP genes (rs2167270 and rs7799039) and two in LEPR genes (rs6588147, rs1137100) for association with CAD.

Methods

We enrolled 271 North Chinese Han CAD patients, and 113 healthy age- and sex-matched controls. Genomic DNA was extracted from whole blood, and the four SNPs were assessed using a MassArray system.

Results

The G allele frequency at rs2167270 was significantly higher among CAD

SUBMITTER: Wang H 

PROVIDER: S-EPMC7083392 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature