A diabetes-associated genetic variant is associated with diastolic dysfunction and cardiovascular disease.

ABSTRACT:

Aims

Although the epidemiological association between Type 2 diabetes and congestive heart failure (CHF) as well as cardiovascular disease (CVD) is well established, associations between diabetes-related single-nucleotide polymorphisms (SNPs), CHF, and CVD have been surprisingly inconclusive. Our aim is to examine if 43 diabetes-related SNPs were associated with prevalent diastolic dysfunction assessed by echocardiography and incident CVD and/or CHF.

Methods and results

We genotyped 43 SNPs that previously reported genome-wide significant associations with Type 2 diabetes, in 1444 subjects from the population-based Malmö Preventive Project-Re-examination Study (MPP-RES) (mean age 68 years; 29% women, 36% prevalent diabetes) (discovery cohort) and in 996 subjects from the VAR

SUBMITTER: Molvin J 

PROVIDER: S-EPMC7083427 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature