Digoxin is associated with worse outcomes in patients with heart failure with reduced ejection fraction.

ABSTRACT:

Aims

The aim of this study was to investigate the impact of digoxin use on the outcomes of patients with heart failure with reduced ejection fraction (HFrEF) and its possible interaction with atrial fibrillation or use of currently guideline-recommended treatments in the real world in China.

Methods and results

Patients hospitalized with HFrEF from 45 hospitals participating in the China National Heart Failure Registration Study (CN-HF) were enrolled to assess the all-cause mortality, HF mortality, all-cause re-hospitalization, and HF re-hospitalization associated with digoxin use. Eight hundred eighty-two eligible HFrEF patients in the CN-HF registry were included: 372 patients with digoxin and 510 patients without digoxin. Among them, 794 (90.0%) patients were followed up

SUBMITTER: Zhou J 

PROVIDER: S-EPMC7083440 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature