Pre-miR-27a rs895819 polymorphism and risk of diffuse large B-cell lymphoma.

ABSTRACT:

Background

Recently, several studies have investigated the relationship between Pre-miR-27a rs895819 polymorphism and risk of various cancers. However, the relationship between rs895819 and diffuse large B-cell lymphoma (DLBCL) has not been well known.

Methods

In this study, we conducted a case-control study to explore the role of Pre-miR-27a rs895819 in risk of DLBCL. The PCR-TaqMan and luciferase assays and in vitro experiments were used to evaluate polymorphism function.

Results

As a result, we found subjects carrying with rs895819 AG/GG genotype had a significantly decreased risk when compared with those carrying the AA genotype. Further qPCR assay showed that the DLBCL patients carrying AG/GG genotypes showed a lower level of mature miR-27a when compared with pat

SUBMITTER: Tang W 

PROVIDER: S-EPMC7083450 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature