Improved pulmonary ¹²⁹ Xe ventilation imaging via 3D-spiral UTE MRI.

ABSTRACT:

Purpose

Hyperpolarized ¹²⁹ Xe MRI characterizes regional lung ventilation in a variety of disease populations, with high sensitivity to airway obstruction in early disease. However, ventilation images are usually limited to a single breath-hold and most-often acquired using gradient-recalled echo sequences with thick slices (~10-15 mm), which increases partial-volume effects, limits ability to observe small defects, and suffers from imperfect slice selection. We demonstrate higher-resolution ventilation images, in shorter breath-holds, using FLORET (Fermat Looped ORthogonally Encoded Trajectories), a center-out 3D-spiral UTE sequence.

Methods

In vivo human adult (N = 4; 2 healthy, 2 with cystic fibrosis) ¹²⁹ Xe images were acquired using 2D gradient-rec

SUBMITTER: Willmering MM 

PROVIDER: S-EPMC7083696 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature