D-glucose weighted chemical exchange saturation transfer (glucoCEST)-based dynamic glucose enhanced (DGE) MRI at 3T: early experience in healthy volunteers and brain tumor patients.

ABSTRACT:

Purpose

Dynamic glucose enhanced (DGE) MRI has shown potential for imaging glucose delivery and blood-brain barrier permeability at fields of 7T and higher. Here, we evaluated issues involved with translating d-glucose weighted chemical exchange saturation transfer (glucoCEST) experiments to the clinical field strength of 3T.

Methods

Exchange rates of the different hydroxyl proton pools and the field-dependent T₂ relaxivity of water in d-glucose solution were used to simulate the water saturation spectra (Z-spectra) and DGE signal differences as a function of static field strength B₀ , radiofrequency field strength B₁ , and saturation time t_sat . Multislice DGE experiments were performed at 3T on 5 healthy volunteers and 3 glioma p

SUBMITTER: Xu X 

PROVIDER: S-EPMC7083699 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature