Optimizing Group Transfer Catalysis by Copper Complex with Redox-Active Ligand in an Entatic State.

ABSTRACT: Metalloenzymes use earth-abundant non-noble metals to perform high-fidelity transformations in the biological world. To ensure chemical efficiency, metalloenzymes have acquired evolutionary reactivity-enhancing tools. Among these, the entatic state model states that a strongly distorted geometry induced by ligands around a metal center gives rise to an energized structure called entatic state, strongly improving the reactivity. However, the original definition refers both to the transfer of electrons or chemical groups, whereas the chemical application of this concept in synthetic systems has mostly focused on electron transfer, therefore eluding chemical transformations. Here we report that a highly strained redox-active ligand enables a copper complex to perform catalytic nitrogen- and c

SUBMITTER: Ren Y 

PROVIDER: S-EPMC7083792 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature