Interventions aiming to reduce time to antibiotics (TTA) in patients with fever and neutropenia during chemotherapy for cancer (FN), a systematic review.

ABSTRACT:

Purpose

Multiple interventions have been developed aiming to reduce time to antibiotics (TTA) in patients with fever and neutropenia (FN) following chemotherapy for cancer. We evaluated their effect to reduce TTA and their impact on important clinical outcomes in a systematic review.

Methods

The search covered seven databases. Biases and quality of studies were assessed with the Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I) tool. Interventions could be implemented in any setting and performed by any person included in the FN management. Absolute change of TTA was the primary outcome. Registration: PROSPERO (CRD42018092948).

Results

Six thousand two hundred ninety-six titles and abstracts were screened, 177 studies were retrieved and 30 studies wer

SUBMITTER: Koenig C 

PROVIDER: S-EPMC7083808 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature