Web Application for Quantification of Traumatic Brain Injury-Induced Cortical Lesions in Adult Mice.

ABSTRACT: Disabilities resulting from traumatic brain injury (TBI) strongly correlate with the cytoarchitectonic part of the brain damaged, lesion area, and type of lesion. We developed a Web application to estimate the location of the lesion on mouse cerebral cortex caused by TBI induced by lateral fluid-percussion injury. The application unfolds user-determined TBI lesion measurements, e.g., from histologic sections to a reference template, and estimates the total lesion area, including the percentage of cortex damaged in different cytoarchitectural cortical regions. The resulting lesion can be visualized on a two-dimensional map of mouse cerebral cortex. The application also visualizes the development of the lesion over time when measurements from multiple time points are available. The web appli

SUBMITTER: Ciszek R 

PROVIDER: S-EPMC7083813 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature