Protein-polymer bioconjugates via a versatile oxygen tolerant photoinduced controlled radical polymerization approach.

ABSTRACT: The immense application potential of amphiphilic protein-polymer conjugates remains largely unexplored, as established "grafting from" synthetic protocols involve time-consuming, harsh and disruptive deoxygenation methods, while "grafting to" approaches result in low yields. Here we report an oxygen tolerant, photoinduced CRP approach which readily affords quantitative yields of protein-polymer conjugates within 2 h, avoiding damage to the secondary structure of the protein and providing easily accessible means to produce biomacromolecular assemblies. Importantly, our methodology is compatible with multiple proteins (e.g. BSA, HSA, GOx, beta-galactosidase) and monomer classes including acrylates, methacrylates, styrenics and acrylamides. The polymerizations are conveniently conducted in pl

SUBMITTER: Theodorou A 

PROVIDER: S-EPMC7083936 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature