Ontology highlight
ABSTRACT:
SUBMITTER: Gil-Lievana E
PROVIDER: S-EPMC7083952 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Gil-Lievana Elvi E Balderas Israela I Moreno-Castilla Perla P Luis-Islas Jorge J McDevitt Ross A RA Tecuapetla Fatuel F Gutierrez Ranier R Bonci Antonello A Bermúdez-Rattoni Federico F
Communications biology 20200320 1
Findings have shown that anterior insular cortex (aIC) lesions disrupt the maintenance of drug addiction, while imaging studies suggest that connections between amygdala and aIC participate in drug-seeking. However, the role of the BLA → aIC pathway in rewarding contextual memory has not been assessed. Using a cre-recombinase under the tyrosine hydroxylase (TH+) promoter mouse model to induce a real-time conditioned place preference (rtCPP), we show that photoactivation of TH+ neurons induced el ...[more]