Load-transfer in the human vertebral body following lumbar total disc arthroplasty: Effects of implant size and stiffness in axial compression and forward flexion.

ABSTRACT: Adverse clinical outcomes for total disc arthroplasty (TDA), including subsidence, heterotopic ossification, and adjacent-level vertebral fracture, suggest problems with the underlying biomechanics. To gain insight, we investigated the role of size and stiffness of TDA implants on load-transfer within a vertebral body. Uniquely, we accounted for the realistic multi-scale geometric features of the trabecular micro-architecture and cortical shell. Using voxel-based finite element analysis derived from a micro-computed tomography scan of one human L1 vertebral body (74-μm-sized elements), a series of generic elliptically shaped implants were analyzed. We parametrically modeled three implant sizes (small, medium [a typical clinical size], and large) and three implant materials (metallic, E = 1

SUBMITTER: Bonnheim NB 

PROVIDER: S-EPMC7084059 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature