CUL3^BPM E3 ubiquitin ligases regulate MYC2, MYC3, and MYC4 stability and JA responses.

ABSTRACT: The jasmonate (JA)-pathway regulators MYC2, MYC3, and MYC4 are central nodes in plant signaling networks integrating environmental and developmental signals to fine-tune JA defenses and plant growth. Continuous activation of MYC activity is potentially lethal. Hence, MYCs need to be tightly regulated in order to optimize plant fitness. Among the increasing number of mechanisms regulating MYC activity, protein stability is arising as a major player. However, how the levels of MYC proteins are modulated is still poorly understood. Here, we report that MYC2, MYC3, and MYC4 are targets of BPM (BTB/POZ-MATH) proteins, which act as substrate adaptors of CUL3-based E3 ubiquitin ligases. Reduction of function of CUL3^BPM in amiR-bpm lines, bpm235 triple mutants, and cul3

SUBMITTER: Chico JM 

PROVIDER: S-EPMC7084108 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature