SOX4-mediated repression of specific tRNAs inhibits proliferation of human glioblastoma cells.

ABSTRACT: Transfer RNAs (tRNAs) are products of RNA polymerase III (Pol III) and essential for mRNA translation and ultimately cell growth and proliferation. Whether and how individual tRNA genes are specifically regulated is not clear. Here, we report that SOX4, a well-known Pol II-dependent transcription factor that is critical for neurogenesis and reprogramming of somatic cells, also directly controls, unexpectedly, the expression of a subset of tRNA genes and therefore protein synthesis and proliferation of human glioblastoma cells. Genome-wide location analysis through chromatin immunoprecipitation-sequencing uncovers specific targeting of SOX4 to a subset of tRNA genes, including those for tRNAi^Met Mechanistically, sequence-specific SOX4-binding impedes the recruitment of TAT

SUBMITTER: Yang J 

PROVIDER: S-EPMC7084149 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature