Context-dependent operation of neural circuits underlies a navigation behavior in Caenorhabditis elegans.

ABSTRACT: The nervous system evaluates environmental cues and adjusts motor output to ensure navigation toward a preferred environment. The nematode Caenorhabditis elegans navigates in the thermal environment and migrates toward its cultivation temperature by moving up or down thermal gradients depending not only on absolute temperature but on relative difference between current and previously experienced cultivation temperature. Although previous studies showed that such thermal context-dependent opposing migration is mediated by bias in frequency and direction of reorientation behavior, the complete neural pathways-from sensory to motor neurons-and their circuit logics underlying the opposing behavioral bias remain elusive. By conducting comprehensive cell ablation, high-resolution behavioral anal

SUBMITTER: Ikeda M 

PROVIDER: S-EPMC7084152 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature