Cell-Penetrating Peptide Modified PEG-PLA Micelles for Efficient PTX Delivery.

ABSTRACT: On account of their excellent capacity to significantly improve the bioavailability and solubility of chemotherapy drugs, amphiphilic block copolymer-based micelles have been widely utilized for chemotherapy drug delivery. In order to further improve the antitumor ability and to also reduce undesired side effects of drugs, cell-penetrating peptides have been used to functionalize the surface of polymer micelles endowed with the ability to target tumor tissues. Herein, we first synthesized functional polyethylene glycol-polylactic acid (PEG-PLA) tethered with maleimide at the PEG section of the block polymer, which was further conjugated with a specific peptide, the transactivating transcriptional activator (TAT), with an approved capacity of aiding translocation across the plasma membrane.

SUBMITTER: Shuai Q 

PROVIDER: S-EPMC7084196 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature