MiR-9 Does Not Regulate Lamin A Expression in Metastatic Cells from Lung Adenocarcinoma.

ABSTRACT: In lung adenocarcinoma, low lamin A expression in pleural metastatic cells has been proposed as a pejorative factor. miR-9 physiologically inhibits the expression of lamin A in neural cells and seems to be a central actor in the carcinogenesis and the metastatic process in lung cancer. Thus, it could be a good candidate to explain the reduction of lamin A expression in lung adenocarcinoma cells. miR-9 expression was analyzed in 16 pleural effusions containing metastatic cells from lung adenocarcinoma and was significantly reduced in patients from the 'Low lamin A expression' group compared to patients from the 'High lamin A expression' group. Then, carcinoma cells selection by fluorescence-activated cell sorting (FACS) was performed according to epithelial membrane antigen (EMA) expression

SUBMITTER: Guinde J 

PROVIDER: S-EPMC7084260 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature