Inhibition of Human Cytomegalovirus Entry into Host Cells Through a Pleiotropic Small Molecule.

ABSTRACT: Human cytomegalovirus (HCMV) infections are wide-spread among the general population with manifestations ranging from asymptomatic to severe developmental disabilities in newborns and life-threatening illnesses in individuals with a compromised immune system. Nearly all current drugs suffer from one or more limitations, which emphasizes the critical need to develop new approaches and new molecules. We reasoned that a 'poly-pharmacy' approach relying on simultaneous binding to multiple receptors involved in HCMV entry into host cells could pave the way to a more effective therapeutic outcome. This work presents the study of a synthetic, small molecule displaying pleiotropicity of interactions as a competitive antagonist of viral or cell surface receptors including heparan sulfate proteoglyc

SUBMITTER: Elste J 

PROVIDER: S-EPMC7084493 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature