Arsenic trioxide (As₂O₃) as a maintenance therapy for adult T cell leukemia/lymphoma.

ABSTRACT:

Background

Adult T-cell leukemia-lymphoma (ATL) is an aggressive mature lymphoid proliferation associated with poor prognosis. Standard of care includes chemotherapy and/or the combination of zidovudine and interferon-alpha. However, most patients experience relapse less than 6 months after diagnosis. Allogeneic stem cell transplantation is the only curative treatment, but is only feasible in a minority of cases. We previously showed in a mouse model that Arsenic trioxide (As₂O₃) targets ATL leukemia initiating cells.

Results

As₂O₃ consolidation was given in 9 patients with ATL (lymphoma n = 4; acute n = 2; and indolent n = 3), who were in complete (n = 4) and partial (n = 3) remission, in stable (n = 1) and in progressive (n = 1)

SUBMITTER: Marcais A 

PROVIDER: S-EPMC7085150 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature