Deciphering the factors that influence participation in studies requiring serial lumbar punctures.

ABSTRACT:

Introduction

Cerebrospinal fluid biomarkers increasingly inform the causes of dementia and may provide objective markers of disease progression. There is a need to decipher participant and procedural factors that promote participation in studies incorporating longitudinal biomarker measures.

Methods

Participant and procedural factors associated with participation in longitudinal biomarker studies were determined in individuals enrolled in studies of memory and aging at the Knight Alzheimer Disease Research Center (Saint Louis, MO, USA).

Results

Complications were encountered following 331 of 1484 lumbar punctures (22.3%; LPs), affecting 280 of 929 participants (30.1%); in >95% complications were minor. Three hundred fifteen of 679 eligible participants (46.4%) complet

SUBMITTER: Day GS 

PROVIDER: S-EPMC7085282 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature