Biomarker potential of brain-secreted extracellular vesicles in blood in Alzheimer's disease.

ABSTRACT:

Introduction

Brain cells secrete extracellular microvesicles (EVs) that cross the blood-brain barrier. Involved in cell-to-cell communication, EVs contain surface markers and a biologically active cargo of molecules specific to their tissue (and cell) of origin, reflecting the tissue or cell's physiological state. Isolation of brain-secreted EVs (BEVs) from blood provides a minimally invasive way to sample components of brain tissue in Alzheimer's disease (AD), and is considered a form of "liquid biopsy."

Methods

We performed a comprehensive review of the PubMed literature to assess the biomarker and therapeutic potential of blood-isolated BEVs in AD.

Results

We summarize methods used for BEV isolation, validation, and novel biomarker discovery, as well as provide ins

SUBMITTER: Badhwar A 

PROVIDER: S-EPMC7085285 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature