Transcription levels and prognostic significance of the NFI family members in human cancers.

ABSTRACT:

Background

The nuclear factor I (NFI) is a family of transcription factors consisting of four distinct but closely related genes, NFIA, NFIB, NFIC and NFIX, which are important in the development of various tissues and organs in mammals. Recent study results have shown that NFI family may play a critical role in the progression of various human tumors and have been identified as key tumor suppressors and oncogenes for many cancers. However, the expression levels and distinctive prognostic values of the NFI family remain poorly explored in most cancers.

Materials and methods

In the present study, the differences in mRNA expression of the NFI family in various cancers were investigated using the Oncomine and TCGA databases, and the mRNA expression, genetic alteration and DNA m

SUBMITTER: Li Y 

PROVIDER: S-EPMC7085295 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature