The Essential Oil from Acori Tatarinowii Rhizome (the Dried Rhizome of Acorus tatarinowii Schott) Prevents Hydrogen Peroxide-Induced Cell Injury in PC12 Cells: A Signaling Triggered by CREB/PGC-1α Activation.

ABSTRACT: Acori Tatarinowii Rhizome (ATR, the dried rhizome of Acorus tatarinowii Schott), a well-recognized traditional Chinese herbal medicine, is prescribed to treat neurological disorders. The essential oil is considered as the active fraction of ATR, and the neuroprotection of ATR essential oil (ATEO) is proven, including the protection against oxidative stress. However, the cellular mechanism of ATEO against oxidative stress has not been fully illustrated. In this study, to investigate the cellular mechanism of ATEO, the cytoprotective effect of ATEO against H₂O₂-induced injury was revealed in PC12 cells. ATEO treatment increased the viability of cells affected by H₂O₂-mediated injury, inhibited reactive oxygen species (ROS) accumulation, and

SUBMITTER: Yan L 

PROVIDER: S-EPMC7085381 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature