Distance disintegration delineates the brain connectivity failure of Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is associated with brain network dysfunction. Network-based investigations of brain connectivity have mainly focused on alterations in the strength of connectivity; however, the network breakdown in AD spectrum is a complex scenario in which multiple pathways of connectivity are affected. To integrate connectivity changes that occur under AD-related conditions, here we developed a novel metric that computes the connectivity distance between cortical regions at the voxel level (or nodes). We studied 114 individuals with mild cognitive impairment, 24 with AD, and 27 healthy controls. Results showed that areas of the default mode network, salience network, and frontoparietal network display a remarkable network separation, or greater connectivity distances, from the r

SUBMITTER: Costumero V 

PROVIDER: S-EPMC7085436 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature