Striatal hypofunction as a neural correlate of mood alterations in chronic pain patients.

ABSTRACT:

Background

Chronic pain and mood disorders share common neuroanatomical substrates involving disruption of the reward system. Although increase in negative affect (NA) and decrease in positive affect (PA) are well-known factors complicating the clinical presentation of chronic pain patients, our understanding of the mechanisms underlying the interaction between pain and PA/NA remains limited. Here, we used a validated task probing behavioral and neural responses to monetary rewards and losses in conjunction with functional magnetic resonance imaging (fMRI) to test the hypothesis that dysfunction of the striatum, a key mesolimbic structure involved in the encoding of motivational salience, relates to mood alterations comorbid with chronic pain.

Methods

Twenty-eight chronic mu

SUBMITTER: Kim M 

PROVIDER: S-EPMC7085448 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature