The effect of network thresholding and weighting on structural brain networks in the UK Biobank.

ABSTRACT: Whole-brain structural networks can be constructed using diffusion MRI and probabilistic tractography. However, measurement noise and the probabilistic nature of the tracking procedure result in an unknown proportion of spurious white matter connections. Faithful disentanglement of spurious and genuine connections is hindered by a lack of comprehensive anatomical information at the network-level. Therefore, network thresholding methods are widely used to remove ostensibly false connections, but it is not yet clear how different thresholding strategies affect basic network properties and their associations with meaningful demographic variables, such as age. In a sample of 3153 generally healthy volunteers from the UK Biobank Imaging Study (aged 44-77 years), we constructed whole-brain struc

SUBMITTER: Buchanan CR 

PROVIDER: S-EPMC7085460 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature