Cerebellar Volume Is Associated with Cognitive Decline in Mild Cognitive Impairment: Results from ADNI.

ABSTRACT: Alzheimer's disease (AD) is a disease with dysfunctional brain network. Previous studies found the cerebellar volume changes over the course of AD disease progression; however, whether cerebellar volume change contributes to the cognitive decline in AD, or its earlier disease stage (i.e., mild cognitive impairment [MCI]) remains unclear. In ADNI, cognitive function was assessed using Alzheimer's Disease Assessment Scale-Cognitive Behavior section (ADAS-Cog). We used linear regression and linear mixed effects models to examine whether cerebellar volume is associated with either baseline cognition or with cognitive changes over time in MCI or in AD. We used logistic regression to assess the relationship between cerebellar volume and disease progression to MCI and AD. We found that cerebellar

SUBMITTER: Lin CY 

PROVIDER: S-EPMC7085462 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature