Risk Factors for First and Subsequent CVD Events in Type 1 Diabetes: The DCCT/EDIC Study.

ABSTRACT:

Objective

The Diabetes Control and Complications Trial (DCCT) and its observational follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) demonstrated the dominant role of glycemia, second only to age, as a risk factor for a first cardiovascular event in type 1 diabetes (T1D). We now investigate the association between established risk factors and the total cardiovascular disease (CVD) burden, including subsequent (i.e., recurrent) events.

Research design and methods

CVD events in the 1,441 DCCT/EDIC participants were analyzed separately by type (CVD death, acute myocardial infarction [MI], stroke, silent MI, angina, percutaneous transluminal coronary angioplasty/coronary artery bypass graft [PTCA/CABG], and congestive heart failure [CHF]) or as composite

SUBMITTER: Bebu I 

PROVIDER: S-EPMC7085803 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature